Sequential monitoring of response-adaptive randomized clinical trials
نویسندگان
چکیده
منابع مشابه
Biases in clinical trials with sequential monitoring
Objectives It is well known that a sequentially monitored clinical trial that stops early for benefit has a crude treatment difference that overestimates the true treatment effect. This has led to extended debate in the literature, with some researchers arguing that early stopping is an important source of bias in meta-analyses of clinical trials. We therefore investigated the implications of e...
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ژورنال
عنوان ژورنال: The Annals of Statistics
سال: 2010
ISSN: 0090-5364
DOI: 10.1214/10-aos796